FDG-Avid Intrathecal Inflammation Following Administration of Intrathecal Methotrexate

Subacute quadriplegic myelopathy following intrathecal methotrexate

Adverse effects of IT chemotherapy include arachnoiditis, lumbosacral radiculopathy, leukoencephalopathy, and myelopathy.[3] MRI findings include T2 hyperintensities in the central and posterior columns, cord swelling, or lateral column contrast enhancement. Vacuolar degeneration of the white matter is usually described in MTX myelopathy. Rarely extensive necrotic myelopathy has been noted.[4] ...

Accidental intrathecal methotrexate overdose.

Brain damage after intrathecal methotrexate.

Ten brains from leukaemic patients given intrathecal methotrexate and 10 from leukaemic patients without intrathecal therapy have been examined. Three of the methodtrexate treated patients appear to have died from their therapy. The histological changes consisted of destruction of oligodendrocytes, sometimes complete over large areas, and sometimes relatively slight. All the patients who surviv...

Intrathecal Triiodothyronine Administration

To determine whether intracerebrally localized iodothyronines produce thyroid hormone-related functional effects, heart rate responses were compared in conscious hypothyroid rats given triiodothyronine (T3) by either the intrathecal or the intravenous route. A significant increase in heart rate occurred within 18 h after 1.5 amol T3/100 g body wt was delivered intrathecally through a cannula pr...

Re: Treatment of accidental intrathecal methotrexate overdose.

Widemann et al. (1) presented data on the use of cerebrospinal fl uid (CSF) exchange to remove methotrexate before carboxypeptidase G 2 (CPDG 2) administration among patients who had an accidental intrathecal methotrexate overdose. They reported that CSF drainage removed 32% – 58% of the methotrexate dose. Although they showed the percent decreases in CSF methotrexate concentration before and a...